4.8 звезд, основано на 77
This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects
Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects
Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules
Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.
It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods
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